In March I wrote a post named Google On Content Delivery Networks & Search Rankings. The answer was yes, but it depends on how you set it up.

An undisclosed CDN company came into the Google Webmaster Help forums asking Google additional questions on how they handle CDNs. His concern was two fold:

Sites might seem to be hosted on multiple IPs
Many many sites use the same small set of IPs

Google’s Pierre Far responded to the question saying:

The CDN Company asked Google about the concern of dynamic IPs and how they can get special classification for their IPs so Google knows what is going on. They, the CDN company, implied that Google has special treatment for large CDNs such as Akamai and they want on that list.

Personally, I don’t think CDNs have to worry about their IPs dynamically changing for domains. I think as long as the IPs are within the same country region the sites and domains and content on them will be fine.

Forum discussion at Google Webmaster Help.